m(6)A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes

The regulation of islet cell biology is critical for glucose homeostasis(1).N(6)-methyladenosine (m(6)A) is the most abundant internal messenger RNA (mRNA) modification in mammals(2). Here we report that the m(6)A landscape segregates human type 2 diabetes (T2D) islets from controls significantly be...

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Detalles Bibliográficos
Autores principales: De Jesus, Dario F, Zhang, Zijie, Kahraman, Sevim, Brown, Natalie K, Chen, Mengjie, Hu, Jiang, Gupta, Manoj K, He, Chuan, Kulkarni, Rohit N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924515/
https://www.ncbi.nlm.nih.gov/pubmed/31867565
http://dx.doi.org/10.1038/s42255-019-0089-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924515/
https://www.ncbi.nlm.nih.gov/pubmed/31867565
http://dx.doi.org/10.1038/s42255-019-0089-9

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