Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit
Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of life. However, no study to date provides direct experimental evidence for the effect of allergic inflammation on the structure and function of medial prefrontal cortex (mPFC) and amygdala, which are essential...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925103/ https://www.ncbi.nlm.nih.gov/pubmed/31863052 http://dx.doi.org/10.1038/s41598-019-55539-3 |
_version_ | 1783481845428518912 |
---|---|
author | Dehdar, Kolsoum Mahdidoust, Shirin Salimi, Morteza Gholami-Mahtaj, Leila Nazari, Milad Mohammadi, Sadeq Dehghan, Samaneh Jamaati, Hamidreza Khosrowabadi, Reza Nasiraei-Moghaddam, Abbas Barkley, Victoria Javan, Mohammad Mirnajafi-Zadeh, Javad Sumiyoshi, Akira Raoufy, Mohammad Reza |
author_facet | Dehdar, Kolsoum Mahdidoust, Shirin Salimi, Morteza Gholami-Mahtaj, Leila Nazari, Milad Mohammadi, Sadeq Dehghan, Samaneh Jamaati, Hamidreza Khosrowabadi, Reza Nasiraei-Moghaddam, Abbas Barkley, Victoria Javan, Mohammad Mirnajafi-Zadeh, Javad Sumiyoshi, Akira Raoufy, Mohammad Reza |
author_sort | Dehdar, Kolsoum |
collection | PubMed |
description | Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of life. However, no study to date provides direct experimental evidence for the effect of allergic inflammation on the structure and function of medial prefrontal cortex (mPFC) and amygdala, which are essential regions for modulating anxiety and its behavioral expression. We assessed the impact of ovalbumin (OVA)-induced allergic inflammation on the appearance of anxiety-like behavior, mPFC and amygdala volumes using MRI, and the mPFC-amygdala circuit activity in sensitized rats. Our findings exhibited that the OVA challenge in sensitized rats induced anxiety-like behavior, and led to more activated microglia and astrocytes in the mPFC and amygdala. We also found a negative correlation between anxiety-like behavior and amygdala volume. Moreover, OVA challenge in sensitized rats was associated with increases in mPFC and amygdala activity, elevation of amygdala delta-gamma coupling, and the enhancement of functional connectivity within mPFC-amygdala circuit – accompanied by an inverted direction of information transferred from the amygdala to the mPFC. We indicated that disrupting the dynamic interactions of the mPFC-amygdala circuit may contribute to the induction of anxiety-related behaviors with asthma. These findings could provide new insight to clarify the underlying mechanisms of allergic inflammation-induced psychiatric disorders related to asthma. |
format | Online Article Text |
id | pubmed-6925103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69251032019-12-23 Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit Dehdar, Kolsoum Mahdidoust, Shirin Salimi, Morteza Gholami-Mahtaj, Leila Nazari, Milad Mohammadi, Sadeq Dehghan, Samaneh Jamaati, Hamidreza Khosrowabadi, Reza Nasiraei-Moghaddam, Abbas Barkley, Victoria Javan, Mohammad Mirnajafi-Zadeh, Javad Sumiyoshi, Akira Raoufy, Mohammad Reza Sci Rep Article Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of life. However, no study to date provides direct experimental evidence for the effect of allergic inflammation on the structure and function of medial prefrontal cortex (mPFC) and amygdala, which are essential regions for modulating anxiety and its behavioral expression. We assessed the impact of ovalbumin (OVA)-induced allergic inflammation on the appearance of anxiety-like behavior, mPFC and amygdala volumes using MRI, and the mPFC-amygdala circuit activity in sensitized rats. Our findings exhibited that the OVA challenge in sensitized rats induced anxiety-like behavior, and led to more activated microglia and astrocytes in the mPFC and amygdala. We also found a negative correlation between anxiety-like behavior and amygdala volume. Moreover, OVA challenge in sensitized rats was associated with increases in mPFC and amygdala activity, elevation of amygdala delta-gamma coupling, and the enhancement of functional connectivity within mPFC-amygdala circuit – accompanied by an inverted direction of information transferred from the amygdala to the mPFC. We indicated that disrupting the dynamic interactions of the mPFC-amygdala circuit may contribute to the induction of anxiety-related behaviors with asthma. These findings could provide new insight to clarify the underlying mechanisms of allergic inflammation-induced psychiatric disorders related to asthma. Nature Publishing Group UK 2019-12-20 /pmc/articles/PMC6925103/ /pubmed/31863052 http://dx.doi.org/10.1038/s41598-019-55539-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Dehdar, Kolsoum Mahdidoust, Shirin Salimi, Morteza Gholami-Mahtaj, Leila Nazari, Milad Mohammadi, Sadeq Dehghan, Samaneh Jamaati, Hamidreza Khosrowabadi, Reza Nasiraei-Moghaddam, Abbas Barkley, Victoria Javan, Mohammad Mirnajafi-Zadeh, Javad Sumiyoshi, Akira Raoufy, Mohammad Reza Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title | Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title_full | Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title_fullStr | Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title_full_unstemmed | Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title_short | Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
title_sort | allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925103/ https://www.ncbi.nlm.nih.gov/pubmed/31863052 http://dx.doi.org/10.1038/s41598-019-55539-3 |
work_keys_str_mv | AT dehdarkolsoum allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT mahdidoustshirin allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT salimimorteza allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT gholamimahtajleila allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT nazarimilad allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT mohammadisadeq allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT dehghansamaneh allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT jamaatihamidreza allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT khosrowabadireza allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT nasiraeimoghaddamabbas allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT barkleyvictoria allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT javanmohammad allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT mirnajafizadehjavad allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT sumiyoshiakira allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit AT raoufymohammadreza allergeninducedanxietylikebehaviorisassociatedwithdisruptionofmedialprefrontalcortexamygdalacircuit |