Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions

Pyruvate, a pivotal glucose metabolite, is an α-ketoacid that reacts with hydrogen peroxide (H(2)O(2)). Its pharmacological precursor, ethyl pyruvate, has shown anti-inflammatory/anti-tissue injury effects in various animal models of disease, but failed in a multicenter clinical trial. Since rodents...

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Detalles Bibliográficos
Autores principales: Guarino, Victoria A., Oldham, William M., Loscalzo, Joseph, Zhang, Ying-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925109/
https://www.ncbi.nlm.nih.gov/pubmed/31862934
http://dx.doi.org/10.1038/s41598-019-55951-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925109/
https://www.ncbi.nlm.nih.gov/pubmed/31862934
http://dx.doi.org/10.1038/s41598-019-55951-9

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