The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the gene encoding ROMK, are associated with urinary levels o...

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Detalles Bibliográficos
Autores principales: Schiano, Guglielmo, Glaudemans, Bob, Olinger, Eric, Goelz, Nadine, Müller, Michael, Loffing-Cueni, Dominique, Deschenes, Georges, Loffing, Johannes, Devuyst, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925250/
https://www.ncbi.nlm.nih.gov/pubmed/31863061
http://dx.doi.org/10.1038/s41598-019-55771-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925250/
https://www.ncbi.nlm.nih.gov/pubmed/31863061
http://dx.doi.org/10.1038/s41598-019-55771-x

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