Locking Two Rigid-body Bundles in an Outward-Facing Conformation: The Ion-coupling Mechanism in a LeuT-fold Transporter

Secondary active transporters use electrochemical gradient of ions to fuel the “uphill” translocation of the substrate following the alternating-access model. The coupling of ions to conformational dynamics of the protein remains one of the least characterized aspects of the transporter function. We...

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Detalles Bibliográficos
Autores principales: Li, Jing, Zhao, Zhiyu, Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925253/
https://www.ncbi.nlm.nih.gov/pubmed/31862903
http://dx.doi.org/10.1038/s41598-019-55722-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925253/
https://www.ncbi.nlm.nih.gov/pubmed/31862903
http://dx.doi.org/10.1038/s41598-019-55722-6

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