Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown. We characterize SERINC5 downregulation activity of 91 primary HIV-1 subtype B nef alleles, including isolates from 45 elite co...

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Detalles Bibliográficos
Autores principales: Jin, Steven W., Alsahafi, Nirmin, Kuang, Xiaomei T., Swann, Shayda A., Toyoda, Mako, Göttlinger, Heinrich, Walker, Bruce D., Ueno, Takamasa, Finzi, Andrés, Brumme, Zabrina L., Brockman, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925589/
https://www.ncbi.nlm.nih.gov/pubmed/31693887
http://dx.doi.org/10.1016/j.celrep.2019.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925589/
https://www.ncbi.nlm.nih.gov/pubmed/31693887
http://dx.doi.org/10.1016/j.celrep.2019.10.007

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