Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC). Here, we found that Smad7 mediates intestinal inflammation by limiting the PDL2/1-PD1 axis in dendr...

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Detalles Bibliográficos
Autores principales: Garo, Lucien P., Ajay, Amrendra K., Fujiwara, Mai, Beynon, Vanessa, Kuhn, Chantal, Gabriely, Galina, Sadhukan, Supriya, Raheja, Radhika, Rubino, Stephen, Weiner, Howard L., Murugaiyan, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925592/
https://www.ncbi.nlm.nih.gov/pubmed/31553906
http://dx.doi.org/10.1016/j.celrep.2019.07.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925592/
https://www.ncbi.nlm.nih.gov/pubmed/31553906
http://dx.doi.org/10.1016/j.celrep.2019.07.065

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