Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

Mutations in Cu/Zn superoxide dismutase (Sod1) have been reported in both familial and sporadic amyotrophic lateral sclerosis (ALS). In this study, we investigated the behavior of heteromeric combinations of wild-type (WT) and mutant Sod1 proteins A4V, L38V, G93A, and G93C in human cells. We showed...

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Detalles Bibliográficos
Autores principales: Brasil, Aline de Araújo, de Carvalho, Mariana Dias Castela, Gerhardt, Ellen, Queiroz, Daniela Dias, Pereira, Marcos Dias, Outeiro, Tiago Fleming, Eleutherio, Elis Cristina Araujo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926019/
https://www.ncbi.nlm.nih.gov/pubmed/31796595
http://dx.doi.org/10.1073/pnas.1902483116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926019/
https://www.ncbi.nlm.nih.gov/pubmed/31796595
http://dx.doi.org/10.1073/pnas.1902483116

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