Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS

Nonribosomal peptide synthetases (NRPSs) generate the core peptide scaffolds of many natural products. These include small cyclic dipeptides such as the insect feeding deterrent peramine, which is a pyrrolopyrazine (PPZ) produced by grass-endophytic Epichloë fungi. Biosynthesis of peramine is cataly...

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Detalles Bibliográficos
Autores principales: Berry, Daniel, Mace, Wade, Grage, Katrin, Wesche, Frank, Gore, Sagar, Schardl, Christopher L., Young, Carolyn A., Dijkwel, Paul P., Leuchtmann, Adrian, Bode, Helge B., Scott, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926027/
https://www.ncbi.nlm.nih.gov/pubmed/31801877
http://dx.doi.org/10.1073/pnas.1913080116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926027/
https://www.ncbi.nlm.nih.gov/pubmed/31801877
http://dx.doi.org/10.1073/pnas.1913080116

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