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Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS

Nonribosomal peptide synthetases (NRPSs) generate the core peptide scaffolds of many natural products. These include small cyclic dipeptides such as the insect feeding deterrent peramine, which is a pyrrolopyrazine (PPZ) produced by grass-endophytic Epichloë fungi. Biosynthesis of peramine is cataly...

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Detalles Bibliográficos
Autores principales:	Berry, Daniel, Mace, Wade, Grage, Katrin, Wesche, Frank, Gore, Sagar, Schardl, Christopher L., Young, Carolyn A., Dijkwel, Paul P., Leuchtmann, Adrian, Bode, Helge B., Scott, Barry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926027/ https://www.ncbi.nlm.nih.gov/pubmed/31801877 http://dx.doi.org/10.1073/pnas.1913080116

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