Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators

The type 2 ryanodine receptor (RyR2) is responsible for releasing Ca(2+) from the sarcoplasmic reticulum of cardiomyocytes, subsequently leading to muscle contraction. Here, we report 4 cryo-electron microscopy (cryo-EM) structures of porcine RyR2 bound to distinct modulators that, together with our...

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Detalles Bibliográficos
Autores principales: Chi, Ximin, Gong, Deshun, Ren, Kang, Zhou, Gewei, Huang, Gaoxingyu, Lei, Jianlin, Zhou, Qiang, Yan, Nieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926060/
https://www.ncbi.nlm.nih.gov/pubmed/31792195
http://dx.doi.org/10.1073/pnas.1914451116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926060/
https://www.ncbi.nlm.nih.gov/pubmed/31792195
http://dx.doi.org/10.1073/pnas.1914451116

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