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Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators
The type 2 ryanodine receptor (RyR2) is responsible for releasing Ca(2+) from the sarcoplasmic reticulum of cardiomyocytes, subsequently leading to muscle contraction. Here, we report 4 cryo-electron microscopy (cryo-EM) structures of porcine RyR2 bound to distinct modulators that, together with our...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926060/ https://www.ncbi.nlm.nih.gov/pubmed/31792195 http://dx.doi.org/10.1073/pnas.1914451116 |