miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy

Unstable CTG expansions in the 3’ UTR of the DMPK gene are responsible for myotonic dystrophy type 1 (DM1) condition. Muscle dysfunction is one of the main contributors to DM1 mortality and morbidity. Pathways by which mutant DMPK trigger muscle defects, however, are not fully understood. We previou...

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Detalles Bibliográficos
Autores principales: Sabater-Arcis, Maria, Bargiela, Ariadna, Furling, Denis, Artero, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926285/
https://www.ncbi.nlm.nih.gov/pubmed/31855836
http://dx.doi.org/10.1016/j.omtn.2019.11.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926285/
https://www.ncbi.nlm.nih.gov/pubmed/31855836
http://dx.doi.org/10.1016/j.omtn.2019.11.012

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