The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies

Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the need for a better understanding of the factors influencing mAb efficacy. Increased levels of oxidative stress associated with several diseas...

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Detalles Bibliográficos
Autores principales: Gurjar, Shalom A., Wheeler, Jun X., Wadhwa, Meenu, Thorpe, Robin, Kimber, Ian, Derrick, Jeremy P., Dearman, Rebecca J., Metcalfe, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926469/
https://www.ncbi.nlm.nih.gov/pubmed/31727737
http://dx.doi.org/10.1074/jbc.RA119.010637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926469/
https://www.ncbi.nlm.nih.gov/pubmed/31727737
http://dx.doi.org/10.1074/jbc.RA119.010637

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