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The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies
Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the need for a better understanding of the factors influencing mAb efficacy. Increased levels of oxidative stress associated with several diseas...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926469/ https://www.ncbi.nlm.nih.gov/pubmed/31727737 http://dx.doi.org/10.1074/jbc.RA119.010637 |