A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations

A mutant mitochondrial genome arising amid the pool of mitochondrial genomes within a cell must compete with existing genomes to survive to the next generation. Even weak selective forces can bias transmission of one genome over another to affect the inheritance of mitochondrial diseases and guide t...

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Detalles Bibliográficos
Autores principales: Chiang, Ason C.-Y., McCartney, Eleanor, O'Farrell, Patrick H., Ma, Hansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926476/
https://www.ncbi.nlm.nih.gov/pubmed/31786061
http://dx.doi.org/10.1016/j.cub.2019.10.060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926476/
https://www.ncbi.nlm.nih.gov/pubmed/31786061
http://dx.doi.org/10.1016/j.cub.2019.10.060

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