A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation

Myostatin, a member of the transforming growth factor β (TGFβ) superfamily, is a key regulator of skeletal muscle mass and a therapeutic target for muscle wasting diseases. We developed a human monoclonal antibody, SRK-015, that selectively binds to and inhibits proteolytic processing of myostatin p...

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Detalles Bibliográficos
Autores principales: Cote, Shaun M., Jackson, Justin, Pirruccello-Straub, Michelle, Carven, Gregory J., Wawersik, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927069/
https://www.ncbi.nlm.nih.gov/pubmed/31347449
http://dx.doi.org/10.1177/2472555219860779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927069/
https://www.ncbi.nlm.nih.gov/pubmed/31347449
http://dx.doi.org/10.1177/2472555219860779

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