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Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalizati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927181/ https://www.ncbi.nlm.nih.gov/pubmed/31870423 http://dx.doi.org/10.1186/s13059-019-1874-1 |