PMP–diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP–isoxazole. We now report that ForI forms novel PMP–diketopiperazine derivatives following incubation with both d...

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Detalles Bibliográficos
Autores principales: Gao, Sisi, Liu, Huanting, de Crécy-Lagard, Valérie, Zhu, Wen, Richards, Nigel G. J., Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927412/
https://www.ncbi.nlm.nih.gov/pubmed/31730149
http://dx.doi.org/10.1039/c9cc06975e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927412/
https://www.ncbi.nlm.nih.gov/pubmed/31730149
http://dx.doi.org/10.1039/c9cc06975e

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