RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits

Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized RILPL1, which may i...

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Detalles Bibliográficos
Autores principales: Lara Ordónez, Antonio Jesús, Fernández, Belén, Fdez, Elena, Romo-Lozano, María, Madero-Pérez, Jesús, Lobbestael, Evy, Baekelandt, Veerle, Aiastui, Ana, López de Munaín, Adolfo, Melrose, Heather L, Civiero, Laura, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927464/
https://www.ncbi.nlm.nih.gov/pubmed/31428781
http://dx.doi.org/10.1093/hmg/ddz201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927464/
https://www.ncbi.nlm.nih.gov/pubmed/31428781
http://dx.doi.org/10.1093/hmg/ddz201

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