Cargando…

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits

Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10. Phosphorylated RAB10 is recruited to centrosome-localized RILPL1, which may i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lara Ordónez, Antonio Jesús, Fernández, Belén, Fdez, Elena, Romo-Lozano, María, Madero-Pérez, Jesús, Lobbestael, Evy, Baekelandt, Veerle, Aiastui, Ana, López de Munaín, Adolfo, Melrose, Heather L, Civiero, Laura, Hilfiker, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927464/ https://www.ncbi.nlm.nih.gov/pubmed/31428781 http://dx.doi.org/10.1093/hmg/ddz201

Ejemplares similares

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
por: Fdez, Elena, et al.
Publicado: (2022)

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization
por: Lara Ordóñez, Antonio Jesús, et al.
Publicado: (2022)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
por: Dhekne, Herschel S, et al.
Publicado: (2021)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations
por: Rivero-Ríos, Pilar, et al.
Publicado: (2020)

LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
por: Kania, Elżbieta, et al.
Publicado: (2023)

Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy
por: Fdez, Elena, et al.
Publicado: (2023)

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2
por: Waschbüsch, Dieter, et al.
Publicado: (2020)

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation
por: Cabezudo, Diego, et al.
Publicado: (2020)

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins
por: Sobu, Yuriko, et al.
Publicado: (2021)

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A
por: Rivero-Ríos, Pilar, et al.
Publicado: (2019)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking
por: Waschbüsch, Dieter, et al.
Publicado: (2019)

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients
por: Fernández, Belén, et al.
Publicado: (2019)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
por: Steger, Martin, et al.
Publicado: (2017)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation
por: Fasiczka, Rachel, et al.
Publicado: (2023)

Investigating the roles and functions of Rab23 in primary ciliogenesis
por: Lim, YS, et al.
Publicado: (2012)

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
por: Vancraenenbroeck, Renée, et al.
Publicado: (2014)

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis
por: Sato, Takashi, et al.
Publicado: (2014)

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
por: De Wit, T., et al.
Publicado: (2018)

Endogenous Rab38 regulates LRRK2’s membrane recruitment and substrate Rab phosphorylation in melanocytes
por: Unapanta, Alexandra, et al.
Publicado: (2023)

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
por: Yeshaw, Wondwossen M., et al.
Publicado: (2023)

In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3
por: Petridi, Stavroula, et al.
Publicado: (2020)

Rab GTPases as Physiological Substrates of LRRK2 Kinase
por: Seol, Wongi, et al.
Publicado: (2019)

Rab GTPases in Parkinson's disease: a primer
por: Lara Ordóñez, Antonio Jesús, et al.
Publicado: (2021)

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
por: Jeong, Ga Ram, et al.
Publicado: (2018)

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System
por: Kuwahara, Tomoki, et al.
Publicado: (2020)

Dual arginine recognition of LRRK2 phosphorylated Rab GTPases
por: Waschbüsch, Dieter, et al.
Publicado: (2021)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
por: Civiero, Laura, et al.
Publicado: (2017)

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
por: Obergasteiger, Julia, et al.
Publicado: (2020)

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
por: Purlyte, Elena, et al.
Publicado: (2017)

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2(+) lysosomes
por: Kluss, Jillian H., et al.
Publicado: (2022)

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson’s Disease
por: Komori, Tadayuki, et al.
Publicado: (2023)

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
por: Eyers, Patrick A.
Publicado: (2016)

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages
por: Lee, Heyne, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dkho3lmd1i3a6gmi3fk4cgpmnf