The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additional contributing mutations. The molecular effects...

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Detalles Bibliográficos
Autores principales: Tijchon, Esther, Yi, Guoqiang, Mandoli, Amit, Smits, Jos G. A., Ferrari, Francesco, Heuts, Branco M. H., Wijnen, Falco, Kim, Bowon, Janssen-Megens, Eva M., Schuringa, Jan Jacob, Martens, Joost H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927605/
https://www.ncbi.nlm.nih.gov/pubmed/31869378
http://dx.doi.org/10.1371/journal.pone.0226435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927605/
https://www.ncbi.nlm.nih.gov/pubmed/31869378
http://dx.doi.org/10.1371/journal.pone.0226435

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