Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...

Descripción completa

Detalles Bibliográficos
Autores principales: Sulea, Traian, Rohani, Nazanin, Baardsnes, Jason, Corbeil, Christopher R., Deprez, Christophe, Cepero-Donates, Yuneivy, Robert, Alma, Schrag, Joseph D., Parat, Marie, Duchesne, Mélanie, Jaramillo, Maria L., Purisima, Enrico O., Zwaagstra, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927761/
https://www.ncbi.nlm.nih.gov/pubmed/31777319
http://dx.doi.org/10.1080/19420862.2019.1682866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927761/
https://www.ncbi.nlm.nih.gov/pubmed/31777319
http://dx.doi.org/10.1080/19420862.2019.1682866

Ejemplares similares