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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927761/ https://www.ncbi.nlm.nih.gov/pubmed/31777319 http://dx.doi.org/10.1080/19420862.2019.1682866 |