Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

vc-MMAE antibody–drug conjugates (ADCs) consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile valine-citrulline (vc) linker. The objective of this study was to characterize the pharmacokinetics (PK) and explore exposure–response rel...

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Detalles Bibliográficos
Autores principales: Li, Chunze, Zhang, Cindy, Li, Zao, Samineni, Divya, Lu, Dan, Wang, Bei, Chen, Shang-Chiung, Zhang, Rong, Agarwal, Priya, Fine, Bernard M., Girish, Sandhya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927763/
https://www.ncbi.nlm.nih.gov/pubmed/31852341
http://dx.doi.org/10.1080/19420862.2019.1699768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927763/
https://www.ncbi.nlm.nih.gov/pubmed/31852341
http://dx.doi.org/10.1080/19420862.2019.1699768

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