Native size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels

Native size-exclusion chromatography-mass spectrometry (nSEC-MS) is an analytical methodology that is appropriate for accurately quantitating the drug-to-antibody ratio (DAR) on a wide variety of interchain cysteine-linked antibody-drug conjugates (ADCs), irrespective of chemotype. In the current pr...

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Detalles Bibliográficos
Autores principales: Jones, Jay, Pack, Laura, Hunter, Joshua H., Valliere-Douglass, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927766/
https://www.ncbi.nlm.nih.gov/pubmed/31769727
http://dx.doi.org/10.1080/19420862.2019.1682895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927766/
https://www.ncbi.nlm.nih.gov/pubmed/31769727
http://dx.doi.org/10.1080/19420862.2019.1682895

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