A new in vitro model of polymyositis reveals CD8(+) T cell invasion into muscle cells and its cytotoxic role

OBJECTIVES: The hallmark histopathology of PM is the presence of CD8(+) T cells in the non-necrotic muscle cells. The aim of this study was to clarify the pathological significance of CD8(+) T cells in muscle cells. METHODS: C2C12 cells were transduced retrovirally with the genes encoding MHC class...

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Detalles Bibliográficos
Autores principales: Kamiya, Mari, Mizoguchi, Fumitaka, Takamura, Akito, Kimura, Naoki, Kawahata, Kimito, Kohsaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927901/
https://www.ncbi.nlm.nih.gov/pubmed/31257434
http://dx.doi.org/10.1093/rheumatology/kez248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927901/
https://www.ncbi.nlm.nih.gov/pubmed/31257434
http://dx.doi.org/10.1093/rheumatology/kez248

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