Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective p...

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Detalles Bibliográficos
Autores principales: Maglione, Marta, Kochlamazashvili, Gaga, Eisenberg, Tobias, Rácz, Bence, Michael, Eva, Toppe, David, Stumpf, Alexander, Wirth, Alexander, Zeug, André, Müller, Franziska E., Moreno-Velasquez, Laura, Sammons, Rosanna P., Hofer, Sebastian J., Madeo, Frank, Maritzen, Tanja, Maier, Nikolaus, Ponimaskin, Evgeni, Schmitz, Dietmar, Haucke, Volker, Sigrist, Stephan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957/
https://www.ncbi.nlm.nih.gov/pubmed/31873156
http://dx.doi.org/10.1038/s41598-019-56133-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957/
https://www.ncbi.nlm.nih.gov/pubmed/31873156
http://dx.doi.org/10.1038/s41598-019-56133-3

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