Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans

Multiple genome-wide association studies have identified non-coding single-nucleotide variants (SNVs) near (e.g., rs10166942[C]) or within (rs17862920[T]) the TRPM8 gene that encodes a cold thermosensor is associated with reduced migraine risk. Furthermore, rs10166942[C]) and rs10166942[T]) are more...

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Detalles Bibliográficos
Autores principales: Gavva, Narender R., Sandrock, Robert, Arnold, Gregory E., Davis, Michael, Lamas, Edwin, Lindvay, Chris, Li, Chi-Ming, Smith, Brian, Backonja, Miroslav, Gabriel, Kristin, Vargas, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927963/
https://www.ncbi.nlm.nih.gov/pubmed/31873179
http://dx.doi.org/10.1038/s41598-019-56295-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927963/
https://www.ncbi.nlm.nih.gov/pubmed/31873179
http://dx.doi.org/10.1038/s41598-019-56295-0

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