Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementia

A significant number of people with Parkinson’s disease (PD) develop dementia in addition to cognitive dysfunction and are diagnosed as PD with dementia (PDD). This is characterized by cortical and limbic alpha synuclein (α-syn) accumulation, and high levels of diffuse amyloid beta (Aβ) plaques in t...

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Detalles Bibliográficos
Autores principales: Yedlapudi, Deepthi, Xu, Liping, Luo, Dan, Marsh, Gregory B., Todi, Sokol V., Dutta, Aloke K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927976/
https://www.ncbi.nlm.nih.gov/pubmed/31873106
http://dx.doi.org/10.1038/s41598-019-55830-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927976/
https://www.ncbi.nlm.nih.gov/pubmed/31873106
http://dx.doi.org/10.1038/s41598-019-55830-3

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