CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I. In addition to mediating bacterial tropism for neurons, PGL-I interacts with Complement Receptor (CR)3 on macrophages (MPs) to promote...

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Detalles Bibliográficos
Autores principales: Doz-Deblauwe, Émilie, Carreras, Florence, Arbues, Ainhoa, Remot, Aude, Epardaud, Mathieu, Malaga, Wladimir, Mayau, Véronique, Prandi, Jacques, Astarie-Dequeker, Catherine, Guilhot, Christophe, Demangel, Caroline, Winter, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928039/
https://www.ncbi.nlm.nih.gov/pubmed/31921172
http://dx.doi.org/10.3389/fimmu.2019.02913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928039/
https://www.ncbi.nlm.nih.gov/pubmed/31921172
http://dx.doi.org/10.3389/fimmu.2019.02913

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