Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera

Proteolysis targeting chimeras (PROTACs) are an emerging strategy for promoting targeted protein degradation by inducing the proximity between targeted proteins and E3 ubiquitin ligases. Although successful degradation of numerous proteins by PROTACs has been demonstrated, the elements that determin...

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Detalles Bibliográficos
Autores principales: Kim, Kidae, Lee, Dong Ho, Park, Sungryul, Jo, Seung-Hyun, Ku, Bonsu, Park, Sung Goo, Park, Byoung Chul, Jeon, Yeong Uk, Ahn, Sunjoo, Kang, Chung Hyo, Hwang, Daehee, Chae, Sehyun, Ha, Jae Du, Kim, Sunhong, Hwang, Jong Yeon, Kim, Jeong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928225/
https://www.ncbi.nlm.nih.gov/pubmed/31873151
http://dx.doi.org/10.1038/s41598-019-56177-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928225/
https://www.ncbi.nlm.nih.gov/pubmed/31873151
http://dx.doi.org/10.1038/s41598-019-56177-5

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