Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations

Phosphoinositide 3 kinase delta (PI3Kδ) is a lipid kinase that has been implicated in a variety of immune mediated disorders. The research on isoform selectivity was crucial for reducing side effects. In the current study, an optimized hierarchical multistage virtual screening method was utilized fo...

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Detalles Bibliográficos
Autores principales: Liang, Jing-wei, Wang, Shan, Wang, Ming-yang, Li, Shi-long, Li, Wan-qiu, Meng, Fan-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928688/
https://www.ncbi.nlm.nih.gov/pubmed/31795217
http://dx.doi.org/10.3390/ijms20236000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928688/
https://www.ncbi.nlm.nih.gov/pubmed/31795217
http://dx.doi.org/10.3390/ijms20236000

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