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Cytosolic Acidification Is the First Transduction Signal of Lactoferrin-Induced Regulated Cell Death Pathway

In yeast, we reported the critical role of K(+)-efflux for the progress of the regulated cell death (RCD) induced by human lactoferrin (hLf), an antimicrobial protein of the innate immune system that blocks Pma1p H(+)-ATPase. In the present study, the K(+) channel Tok1p was identified as the K(+) ch...

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Detalles Bibliográficos
Autores principales: Andrés, María T., Acosta-Zaldívar, Maikel, González-Seisdedos, Jessica, Fierro, José F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928705/
https://www.ncbi.nlm.nih.gov/pubmed/31757076
http://dx.doi.org/10.3390/ijms20235838