Inter-Species Differences in Regulation of the Progranulin–Sortilin Axis in TDP-43 Cell Models of Neurodegeneration

Cytoplasmic aggregates and nuclear depletion of the ubiquitous RNA-binding protein TDP-43 have been described in the autoptic brain tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTLD) patients and both TDP-43 loss-of-function and gain-of-function mechanisms seem to cont...

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Detalles Bibliográficos
Autores principales: Gumina, Valentina, Onesto, Elisa, Colombrita, Claudia, Maraschi, AnnaMaria, Silani, Vincenzo, Ratti, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928728/
https://www.ncbi.nlm.nih.gov/pubmed/31766750
http://dx.doi.org/10.3390/ijms20235866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928728/
https://www.ncbi.nlm.nih.gov/pubmed/31766750
http://dx.doi.org/10.3390/ijms20235866

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