Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action

Roxadustat (FG-4592), an analog of 2-oxoglutarate, is an orally-administered, heterocyclic small molecule known to be an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase. However, none of the studies have thus far thoroughly investigated its possible perturbations on membrane ion curre...

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Detalles Bibliográficos
Autores principales: Chang, Wei-Ting, Lo, Yi-Ching, Gao, Zi-Han, Wu, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928729/
https://www.ncbi.nlm.nih.gov/pubmed/31795416
http://dx.doi.org/10.3390/ijms20236027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928729/
https://www.ncbi.nlm.nih.gov/pubmed/31795416
http://dx.doi.org/10.3390/ijms20236027

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