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QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles
Drugs that accumulate in lysosomes reach very high tissue concentrations, which is evident in the high volume of distribution and often lower clearance of these compounds. Such a pharmacokinetic profile is beneficial for indications where high tissue penetration and a less frequent dosing regime is...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928787/ https://www.ncbi.nlm.nih.gov/pubmed/31779113 http://dx.doi.org/10.3390/ijms20235938 |