Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes

Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis. Dysregulated methionine cycle is reported in animal models of WD, though not verified in humans. Choline is essential for lipid and methionine me...

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Detalles Bibliográficos
Autores principales: Mazi, Tagreed A., Sarode, Gaurav V., Czlonkowska, Anna, Litwin, Tomasz, Kim, Kyoungmi, Shibata, Noreene M., Medici, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928853/
https://www.ncbi.nlm.nih.gov/pubmed/31779102
http://dx.doi.org/10.3390/ijms20235937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928853/
https://www.ncbi.nlm.nih.gov/pubmed/31779102
http://dx.doi.org/10.3390/ijms20235937

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