Cargando…

Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution

Metal ions are well known modulators of protein aggregation and are key players in Alzheimer’s Disease, being found to be associated to pathologic protein deposits in diseased brains. Therefore, understanding how metals influence amyloid aggregation is critical in establishing molecular mechanisms t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreira, Guilherme G., Cristóvão, Joana S., Torres, Vukosava M., Carapeto, Ana P., Rodrigues, Mário S., Landrieu, Isabelle, Cordeiro, Carlos, Gomes, Cláudio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928861/ https://www.ncbi.nlm.nih.gov/pubmed/31783644 http://dx.doi.org/10.3390/ijms20235979

Ejemplares similares

Dynamic interactions and Ca(2+)-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
por: Moreira, Guilherme G., et al.
Publicado: (2021)

Oligomer Diversity during the Aggregation of the Repeat Region of Tau
por: Kjaergaard, Magnus, et al.
Publicado: (2018)

Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
por: Sonawane, Shweta Kishor, et al.
Publicado: (2021)

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation
por: Figueira, António J., et al.
Publicado: (2023)

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2019)

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
por: Shammas, Sarah L., et al.
Publicado: (2015)

Characteristics of Tau Oligomers
por: Ren, Yan, et al.
Publicado: (2013)

Tau Oligomers Neurotoxicity
por: Niewiadomska, Grazyna, et al.
Publicado: (2021)

Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2021)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting
por: Blömeke, Lara, et al.
Publicado: (2022)

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation
por: Garai, Kanchan, et al.
Publicado: (2014)

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
por: Cantrelle, François-Xavier, et al.
Publicado: (2021)

Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases
por: Kamath, Tarun V, et al.
Publicado: (2021)

In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers
por: Zurlo, Enrico, et al.
Publicado: (2021)

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation
por: Lasorsa, Alessia, et al.
Publicado: (2018)

Tau oligomers mediate aggregation of RNA‐binding proteins Musashi1 and Musashi2 inducing Lamin alteration
por: Montalbano, Mauro, et al.
Publicado: (2019)

Small Molecules Present in the Cerebrospinal Fluid Metabolome Influence Superoxide Dismutase 1 Aggregation
por: Cristóvão, Joana S., et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Tau oligomers in cerebrospinal fluid in Alzheimer's disease
por: Sengupta, Urmi, et al.
Publicado: (2017)

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
por: Shafiei, Scott S., et al.
Publicado: (2017)

Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws
por: Silva, Alexandra, et al.
Publicado: (2018)

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER
por: Ano Bom, Ana P. D., et al.
Publicado: (2012)

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
por: Lasagna-Reeves, Cristian A., et al.
Publicado: (2012)

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers
por: Cowan, Catherine M., et al.
Publicado: (2015)

The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer’s Disease (AD)
por: Mroczko, Barbara, et al.
Publicado: (2019)

Effects of zinc and carnosine on aggregation kinetics of Amyloid-β40 peptide
por: Shen, Fengyun, et al.
Publicado: (2022)

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
por: Guerrero-Muñoz, Marcos J., et al.
Publicado: (2015)

Preparation of stable tau oligomers for cellular and biochemical studies
por: Karikari, Thomas K., et al.
Publicado: (2019)

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
por: Lo Cascio, Filippa, et al.
Publicado: (2019)

The prion-like transmission of tau oligomers via exosomes
por: Jackson, Noel A., et al.
Publicado: (2022)

Extracellular Tau Oligomers Damage the Axon Initial Segment
por: Best, Merci N., et al.
Publicado: (2023)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

NMR Meets Tau: Insights into Its Function and Pathology
por: Lippens, Guy, et al.
Publicado: (2016)

A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway
por: Sun, Xun, et al.
Publicado: (2022)

Bacterial DNA promotes Tau aggregation
por: Tetz, George, et al.
Publicado: (2020)

Effect of zinc cations on the kinetics of supramolecular assembly and the chirality of porphyrin J-aggregates
por: Romeo, A., et al.
Publicado: (2017)

Kinetics for Zinc Ion Induced Sepia Pharaonis Arginine Kinase  Inactivation and Aggregation
por: Si, Yue-Xiu, et al.
Publicado: (2016)

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments
por: Cristóvão, Joana S., et al.
Publicado: (2021)

The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity
por: Bi, Timothy M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o9lf14oop8h8e9rhnm8i4k51v2