Amoxicillin Modulates ApoA-I Transcription and Secretion, Predominantly via PPARα Transactivation Inhibition

In a recent human study, we observed that amoxicillin treatment decreased HDL-C concentration. We hypothesize that antibiotics lower the transcription and secretion of ApoA-I, the responsible protein for HDL production. HepG2 and Caco-2 cells were exposed to increasing dose of amoxicillin, penicilli...

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Detalles Bibliográficos
Autores principales: Tayyeb, Jehad Z., Popeijus, Herman E., Mensink, Ronald P., Konings, Maurice C.J.M., Mulders, Kim H.R., Plat, Jogchum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928897/
https://www.ncbi.nlm.nih.gov/pubmed/31783518
http://dx.doi.org/10.3390/ijms20235967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928897/
https://www.ncbi.nlm.nih.gov/pubmed/31783518
http://dx.doi.org/10.3390/ijms20235967

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