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Amoxicillin Modulates ApoA-I Transcription and Secretion, Predominantly via PPARα Transactivation Inhibition

In a recent human study, we observed that amoxicillin treatment decreased HDL-C concentration. We hypothesize that antibiotics lower the transcription and secretion of ApoA-I, the responsible protein for HDL production. HepG2 and Caco-2 cells were exposed to increasing dose of amoxicillin, penicilli...

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Detalles Bibliográficos
Autores principales:	Tayyeb, Jehad Z., Popeijus, Herman E., Mensink, Ronald P., Konings, Maurice C.J.M., Mulders, Kim H.R., Plat, Jogchum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928897/ https://www.ncbi.nlm.nih.gov/pubmed/31783518 http://dx.doi.org/10.3390/ijms20235967

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