Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability

Melanoma is a lethal tumor because of its severe metastatic potential, and serine/threonine-protein kinase B-raf inhibitors (BRAFi) are used in patients harboring BRAF-mutation. Unfortunately, BRAFi induce resistance. Therefore, we tested the activity of onconase (ONC), a cytotoxic RNase variant, ag...

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Detalles Bibliográficos
Autores principales: Raineri, Alice, Fasoli, Sabrina, Campagnari, Rachele, Gotte, Giovanni, Menegazzi, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928899/
https://www.ncbi.nlm.nih.gov/pubmed/31783660
http://dx.doi.org/10.3390/ijms20235980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928899/
https://www.ncbi.nlm.nih.gov/pubmed/31783660
http://dx.doi.org/10.3390/ijms20235980

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