Thrombin Aptamer-Modified Metal–Organic Framework Nanoparticles: Functional Nanostructures for Sensing Thrombin and the Triggered Controlled Release of Anti-Blood Clotting Drugs

This paper features the synthesis of thrombin-responsive, nucleic acid-gated, UiO-68 metal–organic framework nanoparticles (NMOFs) loaded with the drug Apixaban or rhodamine 6G as a drug model. Apixaban acts as an inhibitor of blood clots formation. The loads in the NMOFs are locked by duplex nuclei...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Hai, Karmi, Ola, Willner, Bilha, Nechushtai, Rachel, Willner, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929137/
https://www.ncbi.nlm.nih.gov/pubmed/31795428
http://dx.doi.org/10.3390/s19235260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929137/
https://www.ncbi.nlm.nih.gov/pubmed/31795428
http://dx.doi.org/10.3390/s19235260

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