Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity

It is well established that extracellular proteins that negatively regulate T cell function, such as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death protein 1 (PD-1), can be effectively targeted to enhance cancer immunotherapies and Chimeric Antigen Receptor T cells (C...

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Detalles Bibliográficos
Autores principales: Sitaram, Poojitha, Uyemura, Bradley, Malarkannan, Subramaniam, Riese, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929154/
https://www.ncbi.nlm.nih.gov/pubmed/31756921
http://dx.doi.org/10.3390/ijms20235821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929154/
https://www.ncbi.nlm.nih.gov/pubmed/31756921
http://dx.doi.org/10.3390/ijms20235821

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