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Improving CRISPR guide design with consensus approaches

BACKGROUND: CRISPR-based systems are playing an important role in modern genome engineering. A large number of computational methods have been developed to assist in the identification of suitable guides. However, there is only limited overlap between the guides that each tool identifies. This can m...

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Detalles Bibliográficos
Autores principales: Bradford, Jacob, Perrin, Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929336/
https://www.ncbi.nlm.nih.gov/pubmed/31874627
http://dx.doi.org/10.1186/s12864-019-6291-z