Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis

BACKGROUND: Although disease in a majority of rheumatoid arthritis (RA) patients is often initially limited to one or a few joints, currently approved medications including anti-tumor necrosis factor-α antibody (α-TNF) are injected systemically. Given that α-TNF systemic injection typically does not...

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Detalles Bibliográficos
Autores principales: Katsumata, Kiyomitsu, Ishihara, Jun, Fukunaga, Kazuto, Ishihara, Ako, Yuba, Eiji, Budina, Erica, Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929495/
https://www.ncbi.nlm.nih.gov/pubmed/31870429
http://dx.doi.org/10.1186/s13075-019-2075-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929495/
https://www.ncbi.nlm.nih.gov/pubmed/31870429
http://dx.doi.org/10.1186/s13075-019-2075-8

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