Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts

Our genomic DNA is under constant assault from endogenous and exogenous sources, which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the hydrolysis of phosphodiester bonds that covalently link adducts to DNA-e...

Descripción completa

Detalles Bibliográficos
Autores principales: Brettrager, Evan J., van Waardenburg, Robert C.A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929713/
https://www.ncbi.nlm.nih.gov/pubmed/31875206
http://dx.doi.org/10.20517/cdr.2019.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929713/
https://www.ncbi.nlm.nih.gov/pubmed/31875206
http://dx.doi.org/10.20517/cdr.2019.91

Ejemplares similares