The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

[Image: see text] β-Hydroxylation plays an important role in the nonribosomal peptide biosynthesis of many important natural products, including bleomycin, chloramphenicol, and the glycopeptide antibiotics (GPAs). Various oxidative enzymes have been implicated in such a process, with the mechanism o...

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Detalles Bibliográficos
Autores principales: Kaniusaite, Milda, Goode, Robert J. A., Schittenhelm, Ralf B., Makris, Thomas M., Cryle, Max J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929969/
https://www.ncbi.nlm.nih.gov/pubmed/31774267
http://dx.doi.org/10.1021/acschembio.9b00862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929969/
https://www.ncbi.nlm.nih.gov/pubmed/31774267
http://dx.doi.org/10.1021/acschembio.9b00862

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