In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects

Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dual agonist tesaglitazar to macrophages while reducing drug act...

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Detalles Bibliográficos
Autores principales: Osinski, Victoria, Bauknight, Dustin K., Dasa, Siva Sai Krishna, Harms, Matthew J., Kroon, Tobias, Marshall, Melissa A., Garmey, James C., Nguyen, Anh T., Hartman, Julia, Upadhye, Aditi, Srikakulapu, Prasad, Zhou, Andrea, O'Mahony, Gavin, Klibanov, Alexander L., Kelly, Kimberly A., Boucher, Jeremie, McNamara, Coleen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929996/
https://www.ncbi.nlm.nih.gov/pubmed/31903139
http://dx.doi.org/10.7150/thno.36572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929996/
https://www.ncbi.nlm.nih.gov/pubmed/31903139
http://dx.doi.org/10.7150/thno.36572

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