Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression

Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low argininosuccinate synthetase 1 (ASS1) expression. However, its efficacy as a single agent therapy needs to be improved as resistance is frequently observed. Methods: A tissue microarray was performed to assess ASS1 ex...

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Detalles Bibliográficos
Autores principales: Kim, Stephanie S., Xu, Shili, Cui, Jing, Poddar, Soumya, Le, Thuc M., Hayrapetyan, Hovhannes, Li, Luyi, Wu, Nanping, Moore, Alexandra M., Zhou, Lei, Yu, Alice C., Dann, Amanda M., Elliott, Irmina A., Abt, Evan R., Kim, Woosuk, Dawson, David W., Radu, Caius G., Donahue, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929997/
https://www.ncbi.nlm.nih.gov/pubmed/31903153
http://dx.doi.org/10.7150/thno.40195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929997/
https://www.ncbi.nlm.nih.gov/pubmed/31903153
http://dx.doi.org/10.7150/thno.40195

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